What Is Cryolipolysis? Cryolipolysis is a technique that targets and destroys fat cells by exposing them to extremely cold temperatures . Fat cells are more sensitive to cold than other cells, so they crystallize and die without damaging surrounding tissue (like skin or muscle). ⚙️ How the Procedure Works Target Area Selection : Common areas include the abdomen, flanks (love handles), thighs, back, under the chin, and arms. Device Application : A specialized applicator suctions the skin and underlying fat into a cup-like device. Cooling : The area is cooled for 30–60 minutes, depending on the area and device. Massage : After treatment, the area is often massaged to help break down the frozen fat cells.